Human liver xenotransplantation.
نویسندگان
چکیده
منابع مشابه
Intrauterine xenotransplantation of human Wharton jelly-derived mesenchymal stem cells into the liver of rabbit fetuses: A preliminary study for in vivo expression of the human liver genes
Objective(s): End-stage hepatic failure is a potentially life-threatening condition for which orthotopic liver transplantation is the only effective treatment. However, a shortage of available donor organs for transplantation each year results in the death of many patients waiting for liver transplantation. Xenotransplantation, or the transplantation of cells, tissues, or organs between differe...
متن کاملDetection of infectious baboon cytomegalovirus after baboon-to-human liver xenotransplantation.
Xenotransplantation is considered to be a solution for the human donor shortage. However, there is a potential risk of transmitting animal infections from the transplanted organ. The known transmissibility and clinical significance of human cytomegalovirus (HCMV) infection after allotransplantation led us to evaluate whether baboon cytomegalovirus (BCMV) transmission could occur after a baboon-...
متن کاملIntrauterine xenotransplantation of human Wharton jelly-derived mesenchymal stem cells into the liver of rabbit fetuses: A preliminary study for in vivo expression of the human liver genes
Objectives End-stage hepatic failure is a potentially life-threatening condition for which orthotopic liver transplantation is the only effective treatment. However, a shortage of available donor organs for transplantation each year results in the death of many patients waiting for liver transplantation. Xenotransplantation, or the transplantation of cells, tissues, or organs between different ...
متن کاملO-4: Morphological Analyses and Apoptosis Genes Expression Evaluation in Vitrified Human Ovarian Tissue after Warming, Long Term Culturing and Xenotransplantation
Background In vitro culturing and retransplantion of vitrified- warmed ovarian tissue are two ways to restore fertility after radiation or chemotherapy.This study aimed to evaluate the incidence of apoptosis in vitrified human ovarian tissue after warming, long term culturing and xenotransplantation by morphological analyses and apoptosis genes expression evaluation. MaterialsAndMethods We obta...
متن کاملActivation of porcine hepatic microvascular sinusoidal endothelial cells in pig-to-human liver xenotransplantation.
THE ROLE of the endothelium in mediating rejection in discordant xenotransplantation is currently being defined. The literature has focused on cardiac and renal models of xenotransplantation, and the aortic endothelial cell (AEC) has become the prototypical cell for in vitro studies. The assumption that all EC behave similarly has never been validated. A recent study demonstrated that although ...
متن کاملThe Role of Costimulation Blockade in Solid Organ and Islet Xenotransplantation
Pig-to-human xenotransplantation offers a potential bridge to the growing disparity between patients with end-stage organ failure and graft availability. Early studies attempting to overcome cross-species barriers demonstrated robust humoral immune responses to discordant xenoantigens. Recent advances have led to highly efficient and targeted genomic editing, drastically altering the playing fi...
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عنوان ژورنال:
- Xeno
دوره 1 1 شماره
صفحات -
تاریخ انتشار 1993